Endogenous repair mechanisms in the brain

Abstract

Most of neurons are generated by neural stem cells in the developing brain at the embryonic or neonatal stages. However, recent studies indicate that adult brain also contains neural stem cells that continuously generate new neurons. Neurogenesis can be observed in the adult subventricular zone (SVZ) at the lateral wall of the lateral ventricles of various animal species including primates. Young neurons generated in the SVZ migrate over long distances and mature after they reach their final destinations where they function. In this talk, I will present our recent studies using animal models on the mechanisms of neuronal production, migration and maturation in the adult brain under physiological and pathological conditions, and discuss the possibility of their application into regeneration therapiesfor ischemic brain diseases.