Objective: The objective of present study is to enhance solubility and bioavailability of poorly soluble bacoside A present in Bacopa monnieri extract using self nano emulsifying drug delivery system (SNEDDS) for the treatment of Alzheimer's disease. Methods: Solubility of the drug was assessed in various oils (edible as well as synthetic oil), surfactant and co-surfactant by saturation solubility study. Pseudo-ternary phase diagram was used to obtain appropriate concentration ranges of components include oil, surfactant and co-surfactant. Results: From the result of saturated solubility study and phase diagram, oleic acid, tween 20 and ethanol was selected as oil, surfactant and cosurfactant. The D-Optimal mixture design was used to optimize the formulation on the basis of solubility of drug and dilution potential. In vitro dissolution, study showed 89% of drug release from optimized SNEDDS formulation compared to untreated drug extract with 24% of drug release in 60 min. Ex vivo diffusion study showed more than 90% of drug diffused from optimized SNEDDS formulation compared to pure extract. Conclusion: In a nutshell, the developed SNEDDS formulation using the design of experimentation approach held great potential as a possible alternative to traditional oral formulations of poorly soluble Bacoside A to improve solubility and bioavailability.
CITATION STYLE
Gohel, M., Purohit, A., Patel, A., & Hingorani, L. (2016). Optimization of bacoside a loaded snedds using d-optimal mixture design for enhancement insolubility and bioavailability. International Journal of Pharmacy and Pharmaceutical Sciences, 8(12), 213–220. https://doi.org/10.22159/ijpps.2016v8i12.13488
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