Hyponatremia as a Predictor of Cryptococcal Meningitis and Death among Asymptomatic Persons with HIV and Cryptococcal Antigenemia

Abstract

Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.