Cerebrovascular response to infused 5-hydroxytryptamine in the baboon: Part 2. 5-hydroxytryptamine infusion in estrogen and progesterone treated animals

Abstract

The effect of intracarotid infusion of 5- hydroxytryptamine (5-HT) on cerebral blood flow was studied in five female baboons 7 days after intramuscular injection of slow release estrogen and progesterone. The control values for total cerebral blood flow, grey matter flow, and white matter flow were 38.9,57.5 and 11.0 ml/min/100 gm of tissue respectively. There was a statistically significant decrease in total, grey and white matter blood flow during infusion of 5-HT at dosages ranging from 0.5 to 10.0 Mg/kg/min. The study indicates that in female baboons pretreated with estrogen and progesterone, intracarotid infusion of 5-HT produces a dose dependent decrease in cerebral blood flow, which did not occur in control animals. © 1977 American Heart Association, Inc.