Tacrolimus for ulcerative colitis in children: A multicenter survey in Japan

12Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Background/Aims: Tacrolimus is effective for refractory ulcerative colitis in adults, while data for children is sparse. We aimed to evaluate the effectiveness and safety of tacrolimus for induction and maintenance therapy in Japanese children with ulcerative colitis. Methods: We retrospectively reviewed the multicenter survey data of 67 patients with ulcerative colitis aged <17 years treated with tacrolimus between 2000 and 2012. Patients' characteristics, disease activity, Pediatric Ulcerative Colitis Activity Index (PUCAI) score, initial oral tacrolimus dose, short-term (2-week) and long-term (1-year) outcomes, steroid-sparing effects, and adverse events were evaluated. Clinical remission was defined as a PUCAI score <10; treatment response was defined as a PUCAI score reduction of ≥20 points compared with baseline. Results: Patients included 35 boys and 32 girls (median [interquartile range] at admission: 13 [11-15] years). Thirty-nine patients were steroid-dependent and 26 were steroid-refractory; 20 had severe colitis and 43 had moderate colitis. The initial tacrolimus dose was 0.09 mg/kg/day (range, 0.05-0.12 mg/kg/day). The short-term clinical remission rate was 47.8%, and the clinical response rate was 37.3%. The mean prednisolone dose was reduced from 19.2 mg/day at tacrolimus initiation to 5.7 mg/day at week 8 (P<0.001). The adverse event rate was 53.7%; 6 patients required discontinuation of tacrolimus therapy. Conclusions: Tacrolimus was a safe and effective second-line induction therapy for steroid-dependent and steroid-refractory ulcerative colitis in Japanese children. (Intest Res 2019;17:476-485)

References Powered by Scopus

Fk-506, A Novel Immunosuppressant Isolated From A Streptomyces

1200Citations
N/AReaders
Get full text

Fk-506, A Novel Immunosuppressant Isolated From A Streptomyces Ii. Immunosuppressive Effect Of Fk-506 In Vitro

992Citations
N/AReaders
Get full text

Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study

885Citations
N/AReaders
Get full text

Cited by Powered by Scopus

3D printed tacrolimus suppositories for the treatment of ulcerative colitis

103Citations
N/AReaders
Get full text

Population pharmacokinetics and pharmacogenomics of tacrolimus in Chinese children receiving a liver transplant: Initial dose recommendation

17Citations
N/AReaders
Get full text

Medical management of pediatric inflammatory bowel disease in the Asia-Pacific region: A position paper by the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group

10Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Yanagi, T., Ushijima, K., Koga, H., Tomomasa, T., Tajiri, H., Kunisaki, R., … Shimizu, T. (2019). Tacrolimus for ulcerative colitis in children: A multicenter survey in Japan. Intestinal Research, 17(4). https://doi.org/10.5217/IR.2019.00027

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 2

67%

Researcher 1

33%

Readers' Discipline

Tooltip

Medicine and Dentistry 3

60%

Computer Science 1

20%

Arts and Humanities 1

20%

Article Metrics

Tooltip
Mentions
News Mentions: 1
Social Media
Shares, Likes & Comments: 1

Save time finding and organizing research with Mendeley

Sign up for free