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Journal ArticleOPEN ACCESS

Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors

  • Kumbar M
  • Kamble R
  • Kamble A
  • et al.
International Journal of Medicinal Chemistry (2016) 2016 1-16
DOI: 10.1155/2016/9890630
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Abstract

Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d , 5e , 5f , 5g , 5h , and 5k, have exhibited potent inhibitory activity on PDE.

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Kumbar, M. N., Kamble, R. R., Kamble, A. A., Salian, S. R., Kumari, S., Nair, R., … Prasad, D. J. (2016). Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors. International Journal of Medicinal Chemistry, 2016, 1–16. https://doi.org/10.1155/2016/9890630

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