A novel adipocytokine, omentin, inhibits agonists-induced increases of blood pressure in rats

Abstract

Omentin is a recently identifed adipocytokine, and we previously demonstrated that omentin played anti-infammatory roles in vascular endothelial and smooth muscle cells. We also demonstrated that omentin induced vasodilation in rat isolated blood vessels. However, effects of omentin on blood pressure (BP) are not determined. Here, we examined whether intravenously injected omentin acutely alters BP of Wistar rats. Omentin (0.06-18 μg/kg) alone did not alter BP of Wistar rats. On the other hand, omentin (18 μg/kg) signifcantly inhibited noradrenaline (NA; 2 μg/kg)-induced increases in systolic BP and mean BP. Omentin (18 μg/kg) signifcantly inhibited angiotensin II (1 μg/kg)-induced increases in diastolic BP. Omentin (18 μg/kg) signifcantly inhibited dimorpholamine (3 mg/kg)-induced increases in diastolic BP. Omentin (18 μg/kg) failed to inhibit the NA (0.02-2 μg/kg)-induced increases of systolic BPin the nitric oxide (NO) synthase inhibitor, NG-nitro-l-arginine methyl ester (80 mg/kg, 1 day)-treated Wistar rats. In summary, we for the frst time demonstrated that omentin inhibited agonists-induced increases in BP. The effect of omentin was suggested to be mediated likely via NO-dependent mechanism. © 2013 The Japanese Society of Veterinary Science..