Crystals of biological macromolecules have been observed and grown for well over a century. More effort has been put into biological crystallization in the last few decades due to the importance of X-ray crystal structures, the advent of synchrotron radiation sources, improved computational speed, better software, and the availability of recombinant protein. Here we focus on two important areas of crystal growth: fi rstly, on techniques for stabilizing the protein sample, and secondly, on strategies and approaches for selecting the crystallization cocktails most suitable for different strategies.
CITATION STYLE
Fazio, V. J., Peat, T. S., & Newman, J. (2015). Crystallization: Digging into the past to learn lessons for the future. Methods in Molecular Biology, 1261, 141–159. https://doi.org/10.1007/978-1-4939-2230-7_8
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