Crucial Role of Extracellular Vesicles in Bronchial Asthma

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Abstract

Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for cell-to-cell communications and homeostasis because they contain intracellular proteins and nucleic acids. Epithelial cells from mice suffering from bronchial asthma (BA) secrete more EVs and suppress inflammation-induced EV production. Moreover, microarray analyses of bronchoalveolar lavage fluid have revealed that several microRNAs are useful novel biomarkers of BA. Mesenchymal stromal cell-derived EVs are possible candidates of novel BA therapy. In this review, we highlight the biologic roles of EVs in BA and review novel EV-targeted therapy to help understanding by clinicians and biologists.

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Nagano, T., Katsurada, M., Dokuni, R., Hazama, D., Kiriu, T., Umezawa, K., … Nishimura, Y. (2019, May 27). Crucial Role of Extracellular Vesicles in Bronchial Asthma. International Journal of Molecular Sciences. NLM (Medline). https://doi.org/10.3390/ijms20102589

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