Chemoselective and fast decarboxylative allylation by photoredox catalysis under mild conditions

Abstract

Here we report a visible-light-induced decarboxylative allylation to build C(sp3)-allyl bonds. This allylation reaction works for primary, secondary, tertiary, benzyl, and alpha-heteroatom-substituted alkyl N-acyloxyphthalimides and is compatible with many sensitive functional groups. The reaction is complete in minutes at room temperature and can be run in both organic solvents and neutral aqueous solutions. A series of mechanistic experiments have been implemented and a functional-group-rich oligosaccharide modification is demonstrated with the decarboxylative allylation.