Germinal centers (GC) are the predominant origin of human B cell lymphomagenesis. Transgenic mice in which gene expression is altered specifically in GC B cells have broadened our knowledge about the mechanisms of malignant transformation. However, extensive resources are needed due to the genetic complexity of these mouse models. Thus, bone marrow (BM)-derived chimerism is an attractive approach to study GC B cell derived lymphomagenesis, as it allows for an efficient allocation of resources and reduces the number of animals used.
CITATION STYLE
Kabrani, E., & Sander, S. (2017). Development of mouse model systems of germinal center lymphomas. In Methods in Molecular Biology (Vol. 1623, pp. 233–242). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7095-7_18
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