The effects of the basil (Ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats

1Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.
Get full text

Abstract

This study aims to examine the changes of the Ocimum sanctum treatment on the tumor necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β) in the kidney tissue of the rats, in which the experimental diabetes was induced with streptozotocin (STZ). Forty Sprague Dawley male rats were divided into 5 groups: Diabetes, Diabetes + Ocimum sanctum, Ocimum sanctum, Control, and Sham. The immunohistochemical localization of TNF-α and IL-1β in the kidney tissue was determined by using the streptavidin-biotin-peroxidase method. Strong TNF-α immunoreactivity was determined in the renal cortex of the rats in the Diabetes and Diabetes + Ocimum sanctum groups on 14th days, low immunoreactivity was determined in the rats in Ocimum sanctum, Sham, and Control groups. While strong IL-1β immunoreactivity was observed in the renal cortex of the Diabetes group, moderate IL-1β immunoreactivity was observed in the renal cortex of the Diabetes + Ocimum sanctum and low immunoreactivity was determined in the Ocimum sanctum, Sham, and Control groups. In this study, it was assessed how the polymorphisms, occurring in the cytokine genes of Ocimum sanctum in the rats, in which experimental diabetes was induced, and TNF-α and IL-1β, which was demonstrated to have an important role in the complication development in the diabetic patients affected the renal tissue.

References Powered by Scopus

Systematic review of herbs and dietary supplements for glycemic control in diabetes

707Citations
N/AReaders
Get full text

Metabolic syndrome: Pathophysiology, management, and modulation by natural compounds

691Citations
N/AReaders
Get full text

Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy

544Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Anti-Apoptotic and Anti-Inflammatory Effects of Ginger Extract on Small Intestine Tissue in STZ-Induced Diabetic Rats

2Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Eliş Yildiz, S., Bakir, B., Asker, H., & Karadağ Sari, E. (2021). The effects of the basil (Ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats. Kafkas Universitesi Veteriner Fakultesi Dergisi, 27(3), 315–322. https://doi.org/10.9775/kvfd.2021.25359

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 1

100%

Save time finding and organizing research with Mendeley

Sign up for free