Development of subunit vaccines against shigellosis: An update

Abstract

Shigellosis is a gastrointestinal disease with a signifi cant morbidity and mortality rate; infants living in developing countries are the most-at-risk population. The disease is caused by Shigella spp., a genus comprising 4 species with 50 different serotypes. While several formulations have been proposed, a broadly protective vaccine is not yet available. The generation and characterization of subunit vaccines against Shigella represents a promising opportunity for vaccine development.