Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68

  • Jia X
  • Shen S
  • Lv Y
  • et al.
14Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

Tegument proteins play critical roles in herpesvirus morphogenesis. ORF45 is a conserved tegument protein of gammaherpesviruses; however, its role in virion morphogenesis is largely unknown. In this work, we determined the ultrastructural localization of murine gammaherpesvirus 68 (MHV-68) ORF45 and found that this protein was incorporated into virions around the site of host-derived vesicles. Notably, the absence of ORF45 inhibited nucleocapsid egress and blocked cytoplasmic virion maturation, demonstrating that ORF45 is essential for MHV-68 virion morphogenesis.

Cite

CITATION STYLE

APA

Jia, X., Shen, S., Lv, Y., Zhang, Z., Guo, H., & Deng, H. (2016). Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68. Journal of Virology, 90(16), 7587–7592. https://doi.org/10.1128/jvi.03231-15

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free