Ghrelin, an acylated 28-amino acid peptide, was isolated from the stomach and circulating ghrelin is produced predominantly in the oxyntic mucosa of stomach. In addition to its unique role in regulating mealtime hunger and lipid metabolism, we here review the physiological role of ghrelin in the regulation of insulin release and glucose metabolism. Ghrelin is expressed in pancreatic islets and released into pancreatic microcirculation. Ghrelin inhibits insulin release in mice, rats, and humans. The signal transduction mechanisms of ghrelin in islet β-cells are very unique, being distinct from those utilized for growth hormone release. Pharmacological and genetic blockades of islet-derived ghrelin markedly augment glucose-induced insulin release in vitro. In high-fat diet-induced mildly obese mice, ghrelin-de fi ciency enhances insulin release and prevents impaired glucose tolerance. Thus, manipulation of insulinostatic function of ghrelin-growth hormonesecretagogue receptor system, particularly that in islets, could optimize the amount of insulin release to meet the systemic demand, providing a potential therapeutic application to prevent type 2 diabetes.
CITATION STYLE
Dezaki, K., Damdindorj, B., Kurashina, T., & Yada, T. (2012). Ghrelin’s Novel Signaling in islet β-cells to inhibit insulin secretion and its blockade as a promising strategy to treat type 2 diabetes. In Ghrelin in Health and Disease (pp. 51–71). Humana Press Inc. https://doi.org/10.1007/978-1-61779-903-7_3
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