Preparation of sulfamethazine molecularly imprinted polymer by electron beam irradiation polymerization

Abstract

Molecularly imprinted polymers (MIPs) of sulfamethazine (SMZ) were prepared initiated by election beam irradiation in acetonitrile (ACN) with the use of SMZ as template molecule, acrylamide (MAA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent. The combination of SMZ with MaA and EGDMA was studied by infrared spectroscopy. The adsorption kinetics experiment and selectivity of sulfamethazine imprinted polymers were investigated by ultraviolet spectrometry. The experimental results showed that there was a binding effect among SMZ, MAA and EGDMA. When the molar ratio of SMZ, MAA and EGDMA was 1 : 4 : 20, and the irradiation dose was 150 kGy, the adsorption capacity of MIP for sulfamethazine (Q MIP) was the largest (31 mg•g-1). Furthermore, the imprinting factor (F) was 12.91, and the separation factor (α) for SMZ and sulfonamide (SNM) was 1.77.