During insults and disease blood-borne monocytes can invade brain and spinal cord, contributing to the neuroimmune response together with brain-resident microglia. The specific function of brain-infiltrating monocytes has been difficult to ascertain because of shared marker expression and morphology of these two immune cell types. Here we describe our method of repopulating the brain with circulating monocytes after microglia ablation to investigate the physiology of brain-invading monocytes, which engraft under these conditions.
CITATION STYLE
Varvel, N. H., Ransohoff, R. M., & Neher, J. J. (2019). Functional Analysis of Brain-Engrafted Monocytes After Microglia Ablation in Mouse Models. In Methods in Molecular Biology (Vol. 2034, pp. 293–301). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9658-2_22
Mendeley helps you to discover research relevant for your work.