Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies

13Citations
Citations of this article
24Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Sepsis is a common and deadly condition. Within the current model of sepsis immunobiology, the framing of dysregulated host immune responses into proinflammatory and immunosuppressive responses for the testing of novel treatments has not resulted in successful immunomodulatory therapies. Thus, the recent focus has been to parse observable heterogeneity into subtypes of sepsis to enable personalised immunomodulation. In this Personal View, we highlight that many fundamental immunological concepts such as resistance, disease tolerance, resilience, resolution, and repair are not incorporated into the current sepsis immunobiology model. The focus for addressing heterogeneity in sepsis should be broadened beyond subtyping to encompass the identification of deterministic molecular networks or dominant mechanisms. We explicitly reframe the dysregulated host immune responses in sepsis as altered homoeostasis with pathological disruption of immune-driven resistance, disease tolerance, resilience, and resolution mechanisms. Our proposal highlights opportunities to identify novel treatment targets and could enable successful immunomodulation in the future.

Cite

CITATION STYLE

APA

Shankar-Hari, M., Calandra, T., Soares, M. P., Bauer, M., Wiersinga, W. J., Prescott, H. C., … van der Poll, T. (2024, April 1). Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies. The Lancet Respiratory Medicine. Elsevier Ltd. https://doi.org/10.1016/S2213-2600(23)00468-X

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free