It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective "fail-safe" pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg++] level.
CITATION STYLE
Van Woerkom, A. E. (2017). A fully integrated new paradigm for lithium’s mode of action - lithium utilizes latent cellular fail-safe mechanisms. Neuropsychiatric Disease and Treatment, 13, 275–302. https://doi.org/10.2147/NDT.S123612
Mendeley helps you to discover research relevant for your work.