Sol-Gel Mediated Synthesis of Pure Hydroxyapatite at Different Temperatures and Silver Substituted Hydroxyapatite for Biomedical Applications

Abstract

Owing to excellent bio compatibility and bioactivity of Hydroxyapatite (HAP), it plays a vital role in the field of medicine such as orthopaedic and dental applications. In the present work sol-gel method of synthesizing nano Hydroxyapatite using Calcium hydroxide as calcium source and Orthophosphoric acid as Phosphorus source and maintain the Ca:P ratio as 1:67. The synthesized samples are calcined under different temperature ranging from 400 to 700°C. The crystalline size of the synthesised samples are calculated using X-ray diffraction (XRD), Morphology of the surface by scanning electron microscope (SEM) and (TEM), existence of functional groups were revealed by Fourier transformation IR spectroscopy (FTIR). Thus the studies suggest that the Hydroxyapatite calcined at high temperatures is the best biomaterial for dental applications. Then it was substituted with silver and further studied with XRD, SEM, EDAX, FTIR, TEM, antimicrobial activity.