Measuring elastic properties of single cancer cells by AFM

Abstract

Atomic force microscopy (AFM) enables the measurements of the elastic properties of individual cells in liquids that mimic natural conditions. The single-cell deformability, quantitatively described through the Young’s (elastic) modulus, can be used as a marker of pathological alterations, particularly those observed in cancer progression. Here, the AFM-based measurements and data analysis of mechanical properties of single cancerous cells are presented.