The oocyte-to-embryo transition is a precisely coordinated process in which an oocyte becomes fertilized and transitions to an embryonic program of events. The molecules involved in this process have not been well studied. Recently, a group of interacting molecules in C. elegans have been described as coordinating the oocyte-to-embryo transition with the advancement of the cell cycle. Genes egg-3, egg-4, and egg-5 represent a small class of regulatory molecules known as protein-tyrosine phosphase-like proteins, which can bind phosphorylated substrates and act as scaffolding molecules or inhibitors. These genes are responsible for coupling the movements and activities of regulatory kinase mbk-2 with advancement of the cell cycle during the oocyte-to-embryo transition. © 2011 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Parry, J. M., & Singson, A. (2011). EGG molecules couple the oocyte-to-embryo transition with cell cycle progression. Results and Problems in Cell Differentiation, 53, 135–151. https://doi.org/10.1007/978-3-642-19065-0_7
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