Progress in total syntheses of lindenane-type sesquiterpenoids and their dimers

Abstract

Lindenane-type sesquteripenoids and their dimers, mainly isolated from chloranthaceae, are a big family of natural products, which possess novel polycyclic framework embedded with a sterically congested cyclopentane (ring B), an unusual trans-5/6 ring junction, and an angular methyl group. Moreover, many of them exhibited impressing bioactivities, for example remarkable antifungal activity, toxicity-mediated immunosuppression against B cells, and selective inhibition on the delayed rectifier K+current. In this review, the progress in the total syntheses of lindenane-type sesquiterpenoids and their dimmers is summarized. © 2013 Chinese Chemical Society & SIOC, CAS.