Self-Assembling Lipid Nanoparticles/Nanosystems (SLNN) using hydrophilic solvents: Overview and industrial uses

Abstract

Self-assembling lipid nanoparticle systems come in a variety of structural arrangements, sizes, morphologies, and compositions. Lipid nanoparticles have become a significant option to increase the stability and control the release of many active compounds of interest for pharmaceutical and food and beverage industries allowing the development of safer and more effective formula or products. A comprehensive summary of self-assembling nanoparticle systems is beneficial for the nanoparticle field, both academic and professional toward aiding awareness of the subject and its benefits. An overview of self-assembling lipid nanoparticle systems is presented with emphasis on nanostructures, properties, production methods, and key characteristics of importance for industrial applications. Special emphasis is placed on lamellar phase dispersions, termed liposomes, relevant properties, long history of use, and their key role as vehicle of a variety of therapeutic agents. Additional details of each characteristic of self-assembling lipid nanoparticle systems are presented along with information regarding benefits of particular self-assembling lipid nanoparticle systems. Examples of the self-assembling lipid nanoparticle systems within various industrial sectors including pharmaceutical, cosmetic, nutraceutical, and food and beverage are described, as well as the relevance of self-assembling lipid nanoparticle systems within the particular industrial segment. Additionally, details of value and/or benefit to the specific industrial segment are presented.