Preparation of 2 nm gold nanoparticles for in vitro and in vivo applications

Abstract

Gold nanoparticles have been a versatile tool in recent years for the exploration of biological systems. However, challenges with purification and adequate surface coverage limit the biocompatibility of gold nanoparticles. Here, we describe a detailed procedure for the synthesis, purification, and functionalization of biologically compatible gold nanoparticles for in vitro and in vivo studies. © Springer Science+Business Media New York 2013.