Introduction to Wound Healing and Tissue Repair

Abstract

Restoration of tissue integrity and homeostasis following injury is a fundamental property of all organisms. The repair response is a dynamic, interactive response to tissue damage that involves complex interactions of different classes of resident cells and multiple infiltrating leukocyte subtypes, extracellular matrix molecules, and soluble mediators. The immediate goal in repair is to achieve tissue integrity and homeostasis. To achieve this goal, in most tissues the healing process follows in different organs the principle of sequential phases that overlap in time and space: hemostasis, inflammation, tissue formation, and tissue remodeling.