A division of labor: Asymmetric roles for GPCR subunits in receptor dimers

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Abstract

The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor-G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with.

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Zylbergold, P., & Hébert, T. E. (2009). A division of labor: Asymmetric roles for GPCR subunits in receptor dimers. Nature Chemical Biology. Nature Publishing Group. https://doi.org/10.1038/nchembio0909-608

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