Formulation of effervescent granule from robusta green coffee bean ethanolic extract (coffea canephora)

4Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Introduction: Robusta coffee (Coffea canephora) is one of the many crops cultivated in Aceh, and at present is only being used as a drink. Research has shown the potential of many pharmacological uses for coffee, including its use as a remedy to treat diabetes. Effervescent granules are one of the oral dosage forms that can not only mask the unpleasant taste of bioactive substances, but also have a high aesthetic value and can contain relatively large doses of bioactive substances. Previous research has shown that ethanolic extract of robusta green coffee beans at 100 mg/kg body weight (BW) rat yielded the highest percentage of glucose reduction. On the basis of that research, the dosage was used in this study to be formulated into effervescent granule. Aims: This study aimed to find the best formulation of effervescent granules preparation using various concentrations of effervescent salt that meets the general requirements of effervescent dosage forms. The concentrations of citric acid, tartaric acid, and sodium bicarbonate used in sequence were 7.35%, 14.7%, and 25% (F1); 8.08%, 16.17%, and 27.5% (F2); and 8.82%, 17.64%, and 30% (F3), respectively. Robusta green coffee beans were extracted using the maceration method. Results: Secondary metabolite screening of extract showed that it contained alkaloid, saponin, phenolic, and flavonoid metabolites. Effervescent granules were evaluated and F1 and F2 did not qualify the flowability standard of the granules, whereas F3 qualified in all the evaluation standards. Conclusion: On the basis of these results, F3 produced the best effervescent granules that met the general standards of the effervescent dosage forms.

Cite

CITATION STYLE

APA

Maysarah, H., Sari, I., Faradilla, M., & Kwok, K. (2020). Formulation of effervescent granule from robusta green coffee bean ethanolic extract (coffea canephora). Journal of Pharmacy and Bioallied Sciences, 12(6), S743–S746. https://doi.org/10.4103/jpbs.JPBS_258_19

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free