PReS-FINAL-2016: Bone mineral status in a long-term follow up of juvenile dermatomyositis patients

  • Kristensen V
  • Nielsen S
  • Herlin T
  • et al.
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Abstract

Introduction: Juvenile dermatomyositis (JDM) is a rare autoimmune disease with the onset in childhood involving chronic inflammation of striated muscle and skin. The disease is often leading to severe disability, prolonged decreased physical activity, which together with chronic inflammatory activity, and long-term medical treatment with glucocorticoids, contributes to the well-known risk factors for developing osteopenia or osteoporosis. Only a few studies have followed JDM patients into adulthood. Objective(s): The objective of the present study was to investigate the long-term outcome on bone mineral status in a Danish cohort of patients with JDM. Method(s): A total of 49 patients with JDM diagnosed between 1976 and 2005 were investigated. The female/male ratio was 2.5. The mean age at disease onset was 7 years (range 1.5-16 years) and the mean disease duration was 3.7 years (range 0.7-9 years). The follow-up time ranged from 2 years to 36 years (mean 7 years). Bone mass density (BMD) (g/cm2) was determined by dual X-ray absorptiometry (DXA). T- and Z- scores were calculated from BMD. Definition of osteopenia/ osteoporosis in the adult group was according to the WHO-criteria: Osteopenia: T-score between < -1 SD and > -2.5 SD; Osteoporosis: T-score < -2.5 SD. In the children group < 20 years the guidelines from the International Society for Clinical Densitometry was used: Osteopenia: Z-score < -1 SD; Osteoporosis: Z-score

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Kristensen, V., Nielsen, S., Herlin, T., & Mathiesen, P. (2013). PReS-FINAL-2016: Bone mineral status in a long-term follow up of juvenile dermatomyositis patients. Pediatric Rheumatology, 11(S2). https://doi.org/10.1186/1546-0096-11-s2-p29

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