Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (residues 97-118)

Abstract

Background: A stability control region (SCR) (residues 97-118) is conserved in vertebrate tropomyosins and controls overall stability. Results: An A109L mutation interrupts the transmission of stability information along the coiled-coil, inducing two domains. Conclusion: The optimum stability provided by the SCR is critical for transmission of the stability signal. Significance: Learning how stability information is transmitted along tropomyosin is crucial to understanding function and signaling. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..