Genes in canine articular cartilage that respond to mechanical injury: Gene expression studies with Affymetrix canine GeneChip

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Abstract

The Affymetrix canine GeneChip with 23,836 probe sets was used to look for cartilage genes that are significantly altered in response to mechanical impact. The model using canine articular cartilage explants loaded in vitro has been described previously (Chen et al., J Orthop Res 19:703-711, 2001). It is our hypothesis that genes that are activated or repressed in articular cartilage after impact injury initiate cartilage degeneration, leading to osteoarthritis in dogs. Gene expression of known cartilage genes was generally consistent with cartilage biology. A total of 528 genes were significantly (P

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Burton-Wurster, N., Mateescu, R. G., Todhunter, R. J., Clements, K. M., Sun, Q., Scarpino, V., & Lust, G. (2005). Genes in canine articular cartilage that respond to mechanical injury: Gene expression studies with Affymetrix canine GeneChip. Journal of Heredity, 96(7), 821–828. https://doi.org/10.1093/jhered/esi105

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