Reticulum Cell Sarcoma: An Effector Cell in Antibody-Dependent Cell-Mediated Immunity

  • Ralph P
  • Prichard J
  • Cohn M
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Abstract

A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic, adherence, and phagocytic properties of macrophages. It forms specific rosettes with erythrocytes in the presence of the corresponding anti-serum. The ascites cells mediate antibody-dependent cellular immunity as assayed by release of radioactivity from 51Cr-labeled erythrocytes. The contribution of contaminating host cells in the cytotoxic reaction was ruled out by growing the tumor in F1 mice and removing the host cells by anti-H2 serum and complement. The tumor cells have receptors for IgG2a and IgG2b immunoglobulins. The availability of a pure population of effector cells in the immune system allows study of the biochemical processes pursuant to lysis of foreign cells.

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Ralph, P., Prichard, J., & Cohn, M. (1975). Reticulum Cell Sarcoma: An Effector Cell in Antibody-Dependent Cell-Mediated Immunity. The Journal of Immunology, 114(2_Part_2), 898–905. https://doi.org/10.4049/jimmunol.114.2_part_2.898

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