Prediction of sulfamerazine and sulfamethazine solubility in some cosolvent mixtures using non-ideal solution models

Abstract

Introduction: Experimental Solubilities of sulfamerazine (SMR) and sulfamethazine (SMT) in some (methanol + water), (ethanol + water) and (1-propanol +water) cosolvent mixtures were collected from the literature at five temperatures from 293.15 to 313.15 K. Methodology: The results were analyzed with the van’t Hoff, Apelblat modified, Buchowski-Ksiazaczak λh, van’t Hoff-Yaws model, twoparameter Weibull function model. It was determined that the models that best describe the solubility of these sulfonamides in (alcohol + water) mixtures were the van’t Hoff and Apelblat models, obtaining correlation indices greater than 0.99 in all cases. Results: The results obtained with the Modified Apelblat equation presents a high correlation index for the solubility of SMR and SMT in cosolvent mixtures, followed by the van’t Hoff-Yaws model that presents a high fit of the estimated data with respect to the theoretical ones. According to the two-parameter Weibull function model, the solubility of SMR and SMT in the co-solvent mixtures shows important deviations from ideality, which is consistent with the literature. The results are discussed in terms of the solute-solvent interactions that occur in this system