Age-related chronic inflammation is characterized as the unresolved low-grade inflammatory process underlying the ageing process and various age-related diseases. In this chapter, we review the age-related changes in the oxidative stress-sensitive pro-inflammatory NF-κB signaling pathways causally linked with chronic inflammation during ageing based on senoinflammation schema. We describe various age-related dysregulated pro- and anti-inflammatory cytokines, chemokines, and senescence-associated secretory phenotype (SASP), and alterations of inflammasome, specialized pro-resolving lipid mediators (SPM), and autophagy as major players in the chronic inflammatory intracellular signaling network. A better understanding of the molecular, cellular, and systemic mechanisms involved in chronic inflammation in the ageing process would provide further insights into the potential anti-inflammatory strategies.
CITATION STYLE
Chung, K. W., Kim, D. H., Jung, H. J., Arulkumar, R., Chung, H. Y., & Yu, B. P. (2023). Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-Related Diseases. In Subcellular Biochemistry (Vol. 103, pp. 31–44). Springer Science and Business Media B.V. https://doi.org/10.1007/978-3-031-26576-1_3
Mendeley helps you to discover research relevant for your work.