Neuronal tryptophan hydroxylase (TPH2) in suicidal behaviour

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a signalling molecule involved in many brain functions as well as in a variety of psychiatric conditions, including suicidal behaviour. Tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT biosynthesis, plays a critical role in 5-HT metabolism and thus in the regulation of 5-HT neurotransmission. There are two isoforms of TPH, so-called peripheral (TPH1) and neuronal (TPH2), encoded by the two distinct genes. TPH1 is abundant in the peripheral tissues, while TPH2 was detected exclusively within the nervous system. Since its discovery in 2003, TPH2 gene has attracted great interest as a potential factor contributing to diathesis of suicidal behaviour. However, initial positive findings indicating an association of TPH2 genetic variants with suicide have not been replicated consistently. Here we provide an overview of published studies to date, that have evaluated the contribution of TPH2 gene to the etiopathogenesis of suicidal beha viour. © Versita Sp. z o.o.