Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring

Abstract

Prognostic factors and treatment outcome of 71 patients with non- Hodgkin's lymphoma of Waldeyer's ring were analyzed retrospectively. In univariate analyses, unfavorable prognosis was associated with primary disease in the base of the tounge, stage III IV diseases, B-symptoms, high- grade histology, T-cell phenotype, elevated serum LDH levels, decreased peripheral blood lymphocyte counts, and negative response on delayed type hypersensitivity skin reactions. Multivariate analysis showed that stage III IV and T-cell phenotype were significant independent risk factors for death. In stage I II lymphomas, patients with unilateral large or bilateral cervical lymph node involvement had a poorer prognosis. In stage I II lymphomas with intermediate or high-grade histology, patients who had received radiotheraphy with MTCOP-P chemotherapy (pirarubucin, cyclophosphamide, vincristine, methotrexate with leucovorin rescue, peplomycin, and predonisolone) showed significantly better 5-year disease-free survival rate compared with patients treated with radiotherapy alone.