Synthesis, characterization and anti-inflammatory activity of certain novel 2, 4-disubstituted 1,3-thiazole derivatives

Abstract

A series of 2,4-disubstituted thiazole derivatives (6a-k) were synthesized by a condensation reaction between 2-amino, 4-substituted phenyl thiazole and 2-(2,3-dimethylanilino)benzoic acid. The structure of synthesized thiazole derivatives 6(a-k) were characterized by using IR, NMR, Mass Spectroscopy and evaluated for their in vitro anti-inflammatory activity using albumin denaturation method and compared with standard drug diclofenac sodium. The compounds 2-(2,3-dimethyl phenylamino)-N-(4-(4-methyl phenyl) thiazol-2-yl)benzamide (6a) and 2-(2,3-dimethyl phenylamino)-N-(4-(4-nitrophenyl) thiazol-2-yl)benzamide (6c) showed better anti-inflammatory activity when compared with a standard drug.