Monoamine oxidase inhibitory constituents from Anixiella micropertusa

Abstract

Two known naturally-occurring constituents, 1,7-dihydroxy-3- methylxanthone and emodin, were isolated from an Ascomycete Anixiella micropertusa as inhibitors of mouse monoamine oxidase (MAO), together with four non-MAO inhibitory components, including two novel compounds. 1,7- Dihydroxy-3-methylxanthone and emodin inhibited MAO moderately, and IC50 values were calculated to be 2.06 x 10-5 and 3.70 x 10-5 M, respectively.