Laryngeal transplantation

Abstract

The concept of human laryngeal transplantation was first introduced into the literature in the 1960s, with experiments using the dog model by Boles, Ogura, and Silver. In 1969, Kluyskens attempted to treat a laryngeal cancer by transplantation. This transplant was subtotal, preserving recipient perichondrium to revascularize the donor organ without the use of vascular or neural anastomoses. The rapid recurrence of the tumor quashed interest in the procedure for nearly two decades.