Genetic control of schistosome infections by the SM1 locus of the 5q31- q33 region is linked to differentiation of type 2 helper T lymphocytes

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Abstract

Human susceptibility to Schistosoma mansoni infections is controlled by the SM1 locus on chromosome 5 in q31-q33. This genetic region encodes cytokines which regulate the development of helper T lymphocytes. In the present work, a clonal analysis of CD4+ T lymphocytes of homozygous resistant and homozygous susceptible subjects was undertaken to evaluate whether SM1 controls helper T-cell differentiation. Of 121 CD4+ T-cell clones (TCC) from three susceptible (S) and three resistant (R) subjects, 68 proliferated when stimulated by parasite antigens. Parasite-specific TCC derived from susceptible subjects (33 STCC) produced 10- to 1,000-fold less interleukin-4 and -5 than TCC from resistant subjects (25 RTCC). Clones from both patient groups produced, however, the same amount of gamma interferon. Parasite-specific STCC were type 1 helper (Th1) or Th0/1, whereas RTCC were either Th2 or Th0/2. These results, together with the localization of SM1 in 5q31-q33, indicate that the SM1 locus controls the differentiation of Th2 lymphocytes.

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Rodrigues, V., Piper, K., Couissinier-Paris, P., Bacelar, O., Dessein, H., & Dessein, A. J. (1999). Genetic control of schistosome infections by the SM1 locus of the 5q31- q33 region is linked to differentiation of type 2 helper T lymphocytes. Infection and Immunity, 67(9), 4689–4692. https://doi.org/10.1128/iai.67.9.4689-4692.1999

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