Antioxidant capacity of Nitraria retusa leaf extracts against mitomycin C-induced genetic toxicity in male mice

Abstract

Recently, a great interest in the usage of new derived drugs extracted from plant has been increased to treat and/or prevent several diseases including cancer. Therefore, the present study was conducted to use Nitraria retusa leaf extract to increase the antioxidant activity and reduce the genotoxic activity of chemotherapeutic drugs mitomycin C (MMC) in male mice. Male Swiss albino mice (n = 80) were divided in several experimental groups and treated with single dose of MMC with supplementation of 50 and 100 mg/kg body wt Nitraria retusa leaf extract for several time intervals (3 days, 1 week, and 1 month).