Iron-filled multiwall carbon nanotubes (Fe@MWCNTs) were functionalized toward a variety of potential magnetic resonance imaging contrast agents. Oxidized Fe@MWNCTs were covered with PEG5000 via direct esterification or using acyl chloride derivatives. Alternatively, the latter were functionalized with an aminophenol ligand (Fe@O-MWCNT-L). Moreover, pristine Fe@MWCNTs were functionalized with N-phenylaziridine groups (Fe@f-MWCNT) via [2+1] cycloaddition of nitrene. All of these chemically modifed nanotubes served as a vehicle for anchoring Fe3+ ions. The new hybrids - Fe(III)/Fe@(f-/O-)MWCNTs -containing 6%-14% of the “tethered” Fe3+ ions were studied in terms of the acceleration of relaxation of water protons in nuclear magnetic resonance. The highest transverse relaxivity r2=63.9±0.9 mL mg-1 s-1 was recorded for Fe(III)/Fe@O-MWCNT-L, while for Fe(III)/ Fe@f-MWCNT, with r2=57.9±2.9 mL mg-1 s-1, the highest impact of the anchored Fe(III) ions was observed. The T1/T2 ratio of 30-100 found for all of the nanotube hybrids presented in this work is a very important factor for their potential application as T2 contrast agents. Increased stability of the hybrids was confrmed by ultraviolet-visible spectrophotometry.
CITATION STYLE
Kuźnik, N., Tomczyk, M. M., Wyskocka, M., Przypis, Ł., Herman, A. P., Jędrysiak, R., … Boncel, S. (2015). Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents. International Journal of Nanomedicine, 10, 3581–3591. https://doi.org/10.2147/IJN.S81381
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