CCR5Δ32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Δ32 homozygous individual

20Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.

Abstract

Background: Homozygosity (Δ32/Δ32 for the 32 bp deletion in the chemokine receptor 5 (CCR5) gene is associated with strong resistance against HIV infection Heterozygosity is associated with protection of HIV-1 diseases progression. Methodology/Principal Findings: We genotyped a population of 737 HIV-positive adults and 463 healthy controls for the CCR5Δ32 deletion and found heterozygous frequencies of 16.2% (HIV-negative) and 17.5% (HIV-positive) among Caucasian individuals. Analysis of CCR5Δ32 influences on disease progression showed notably lower viral setpoints and a longer time to a CD4 count of <200 λ -1 in seroconverters heterozygous for the deletion. Furthermore, we identified one HIV-positive man homozygous for the Δ32 deletion. Conclusions/Sgnificance: the protective effect of CCR5 Δ32 heterozygosity is confimed in a large cohort of German seroconverters. The HIV-infected CCR5 Δ32 homozygous individual, however, displays extremely rapid disease progression. This is the 12th case of HIV-infection in this genotype described worldwide. © 2008 Oh et al.

Cite

CITATION STYLE

APA

Oh, D. Y., Jessen, H., Kücherer, C., Neumann, K., Oh, N., Poggensee, G., … Hamouda, O. (2008). CCR5Δ32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Δ32 homozygous individual. PLoS ONE, 3(7). https://doi.org/10.1371/journal.pone.0002747

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free