Potpourri of Quick Morphologic References

Abstract

Site Breast Cervix, squamous cell carcinoma (stage 1AI) Ovary, serous borderline tumor Ovary, mucinous borderline tumor Salivary gland, carcinoma ex-mixed tumor Upper aerodigestive tract Lung (minimally invasive adenocarcinoma arising Size Criteria Isolated tumor cells: <0.2 mm (or <200 cells) Micrometastasis: >0.2 mm but <2 mm <0.5 cm (+ low-grade cytology, though not all experts agree on an arbitrary size cutoff between AAH and BAC) <0.5 cm <0.5 cm f islet cell <0.5 cm <1 cm versus >1 cm (this is generally a clinical distinction) <0.5 cm <1 cm _ <1 cm Criteria for Micro-Invasion in Various Organs Size Criteria for micro-invasion <1 mm (some experts use 2 mm) <3mm deep and <7 mm horizontal extent (controversial) Diagnosed by microscopy only, i.e. no grossly visible lesion in a specimen with negative margins <3-5mm or <10 mm2 <3-5 mm or <10 min2 (WHO) .1.5 mm beyond the tumor capsule (minimally invasive) 1-2 mm below the basement membrane in BAC) <5 mm focus of invasion in a lepidic tumor (BAC) that is .3cm in overall size (new proposal) [68] Abbreviations: BAC bronchioloalveolar carcinoma