Pathophysiology: Loss of β-cell function

Abstract

The pathophysiology of prediabetes is a direct extension of the physiology of glucose control. In fact, all evidence indicates that progression from normoglycemia to dysglycemia to frank hyperglycem a occurs along a continuum not just of plasma glucose concentrations but also of underlying mechanisms. Therefore, the pathophysiology of prediabetes can be described equally well as shifts in glucose tolerance category and in terms of continuous changes in glucose parameters [1].