Improved efficacy of α‐particle–targeted radiation therapy

Abstract

The authors investigated the potential of targeting 2 distinct molecules in tumors with high linear energy transfer radioimmunotherapy for the management and treatment of cancer patients who presented with disseminated peritoneal disease. The intent of developing a treatment regimen using α‐targeted radiation was to expand the therapeutic repertoire to patient populations beyond those with pancreatic or ovarian cancer to patients with cancers of the colon, stomach, and small intestine, which result in peritoneal carcinomatosis, and to patients with peritoneal mesothelioma.