Fortuneanosides G-L, dibenzofuran glycosides from the fruit of pyracantha fortuneana

Abstract

Six new dibenzofuran glycosides, fortuneanosides G (1), H (2), I (3), J (4), K (5), and L (6), were isolated from the fruit of Pyracantha fortuneana (MAXIM) LI. Their structures were determined to be 3,7-dihydroxy-2,4-dimethoxy- dibenzofuran 7-O-β-D-glucopyranoside, 3,7-dihydroxy-2,4-dimethoxy- dibenzofuran 7-O-(α-L-rhamnopyranosyl)-(1-6)-β-D-glucopyranoside, 3,6-dihydroxy-2,4-dimethoxy-dibenzofuran 6-O-β-D-glucopyranoside, 2,4-dimethoxy-3,6,9-trihydroxy-dibenzofuran 6-O-β-D-glucopyranoside, 3,9-dihydroxy-2,4-dimethoxydibenzofuran 3-O-β-D-glucopyranoside, and 2-methoxy-3,4,9-trihydroxy-dibenzofuran 4-O-β-D-glucopyranoside based on spectroscopic analysis. Fortuneanosides G-J showed more potent tyrosinase-inhibitory activity than arbutin. © 2008 Pharmaceutical Society of Japan.