Corrigendum to: Water-Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4-Oxadiazoles (Angew. Chem. Int. Ed, (2016), 55, 10.1002/anie.201511730)

Abstract

In this Communication, the following mistakes need to be corrected: Page 3997: The sentence “Therefore, the synthesis of isoxazolines and isoxazoles is carried out in solvents containing bases as catalysts” should be corrected as “Therefore, the synthesis of isoxazolines and isoxazoles is carried out in solvents containing bases.” The minor regioisomer of individual isoxazolines shown in Scheme 2 and Figure 2S (Supporting Information) and isoxazoles displayed in Scheme 5 and Figure 5S might be present in the crude products; details of regioisomers of some compounds were previously reported by Huisgen and co-workers.[1] Page 3999: The claim that “the preparation of the novel hybrid isoxazoline-oxadiazoles presented here has never been reported” is wrong. The hybrid isoxazoline-oxadiazole was previously reported by Bettinetti and Gamba in 1970.[2] However, the spectroscopic and crystallographic determination of the stereochemistry of this compound class has been successfully established in the current work. Page 3999: “… converted into (bis)6bo during crystallization, and it has a plane of symmetry (meso form)”. The optical rotation of (bis)6bo that was incorrectly measured to a close-to-zero value led to the wrong conclusion that (bis)6bo has meso form. The correct optical rotation of (bis)6bo is -289.0 (c=0.42 in DMSO). Moreover, after examining X-ray crystallographic data, it was found that (bis)6bo has a pseudo-twofold axis through the bridge oxygen atom; therefore it is a chiral molecule. Page 4000: In Scheme 5, the structure of 8dh needs to be revised as shown below. (Figure Presented.) The authors sincerely apologize for these errors. They are grateful to Prof. Manfred Christl, University of Würzburg, for helpful comments