Serological misdiagnosis of acute liver failure associated with echovirus 25 due to immunological similarities to hepatitis a virus and prozone effect

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Abstract

We describe a case of acute liver failure caused by echovirus 25 (E25) in a previously healthy 2-year-old boy. Initial serological studies were consistent with hepatitis A virus (HAV), with prozone phenomenon. The similarity of E25 to HAV may obscure accurate diagnosis in some cases of hepatitis.

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Wollersheim, S. K., Humphries, R. M., Cherry, J. D., & Krogstad, P. (2015). Serological misdiagnosis of acute liver failure associated with echovirus 25 due to immunological similarities to hepatitis a virus and prozone effect. Journal of Clinical Microbiology, 53(1), 309–310. https://doi.org/10.1128/JCM.02724-14

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