Non-alcoholic fatty liver disease (NAFLD) is an increasingly important cause of chronic liver disease globally. Similar to metabolic syndrome and obesity, NAFLD is associated with alternations in the gut microbiota and its related biological pathways. While the exact pathophysiology of NAFLD remains largely unknown, changes in intestinal inflammation, gut permeability, energy harvest, anaerobic fermentation and insulin resistance have been described. In this chapter, we review the relationship between the gut microbiota, obesity and NAFLD, and highlight potential ways to modify the gut microbiota to help managing NAFLD patients.
CITATION STYLE
Lau, L. H. S., & Wong, S. H. (2018). Microbiota, obesity and NAFLD. In Advances in Experimental Medicine and Biology (Vol. 1061, pp. 111–125). Springer New York LLC. https://doi.org/10.1007/978-981-10-8684-7_9
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